IO takes a platform-based approach to attack the key barriers discussed above, which would then make it easy to extend it for other diseases in the future. Solution combines several transformational technologies in the market – computer-vision, machine-learning, cloud-orchestrated delivery and processes, and the ubiquitous smartphone. And at the same time, it avoids the complexity so that it is easily used by the average support staff in a primary-care physician (or generalist) office. It takes the easily available ophthalmoscope (which is generally used only by eye specialists, i.e., Ophthalmologists, who knows specific things to examine with it), pairs it with the camera of a smartphone. The combination is then easy-to-use by a staff member to make a video recording of the back of the eye of the patient. IO’s software runs its algorithms to ensure there is adequate quality (i.e., presence of necessary elements), and instructs the staff member to re-take by making the provided adjustments (e.g., focus or angle) if needed. Once the recording is complete, it then creates the technical analysis to aid the eye-specialist in his examination, and sends it, over its secure and HIPAA (i.e., medical and privacy protection regulations in USA) compliant cloud, along with all the associated patient details to the eye specialist with account on its network. This makes it easy for the Ophthalmologist, who can be located anywhere in the world, to complete an asynchronous evaluation and provide report back (along with appropriate recommendations – either no issues or a follow-up for treatment of the identified disease condition) to the primary-care physician who then contacts the patient and stay involved in the care.